Structural effects of point mutations in proteins

Structural Effects of Framework Mutations

evaluation of systemic effects of ginger fractions on salivation in rats

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MutaProt: a web interface for structural analysis of point mutations

A web-based tool, termed 'MutaProt', is described which analyses pairs of PDB files whose members differ in one, or two, amino acids. MutaProt examines the micro environment surrounding the exchanged residue(s) and can be searched by specifying a PDB ID, keywords, or any pair of amino acids. Detailed information about accessibility of the exchanged residue(s) and its atomic contacts are provide...

Predicting the Eect of Point Mutations On Protein Structural Stability

Predicting how a point mutation alters a protein’s stability can guide drug design initiatives which aim to counter the e‚ects of serious diseases. Mutagenesis studies give insights about the e‚ects of amino acid substitutions, but such wet-lab work is prohibitive due to the time and costs needed to assess the consequences of even a single mutation. Computational methods for predicting the e‚ec...

Mu Opioid Receptor Gene: New Point Mutations in Opioid Addicts

Introduction: Association between single-nucleotide polymorphisms (SNPs) in mu opioid receptor gene and drug addiction has been shown in various studies. Here, we have evaluated the existence of polymorphisms in exon 3 of this gene in Iranian population and investigated the possible association between these mutations and opioid addiction.  Methods: 79 opioid-dependent subjects (55 males, 24...